个人简介

主要研究方向

炎症性疾病及其治疗药物发现和机制研究

主要学术成果

学术论文：   
(1) Zhang Y, Wang J, Jing C, Zhou MX, Jin W, Yan X, Hou H, Shi K, Sun WC(*), Sun L(*). Purple tea water extract blocks RANKL-induced osteoclastogenesis through modulation of Akt/GSK3β and Blimp1-Irf8 pathways. Food Funct. 2022 Aug 30;13(17):8850-8859.
(2) Cao J, Zhou MX, Chen X, Sun M, Wei C, Peng Q, Cheng Z(*), Sun W(*), Wang H(*). Sec-O-Glucosylhamaudol Inhibits RANKL-Induced Osteoclastogenesis by Repressing 5-LO and AKT/GSK3β Signaling. Front Immunol. 2022 Apr 26;13:880988.
(3) Cao J, Wang S, Wei C, Lin H, Zhang C, Gao Y, Xu Z, Cheng Z(*), Sun WC(*), Wang HB(*). Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice. Int Immunopharmacol. 2021 Jan;90:107137.
(4) Hou H, Peng Q, Wang S, Zhang Y, Cao J, Deng Y, Wang Y(*), Sun WC(*), Wang HB(*). Anemonin Attenuates RANKL-Induced Osteoclastogenesis and Ameliorates LPS-Induced Inflammatory Bone Loss in Mice via Modulation of NFATc1. Front Pharmacol. 2020 Feb 10;10:1696.
(5) Zhang Y, Wang Z, Xie X, Wang S, Wang Y, Quan G, Wang H(*), Sun WC(*). Tatarinan T, an α-asarone-derived lignin, attenuates osteoclastogenesis induced by RANKL via the inhibition of NFATc1/c-Fos expression. Cell Biol Int. 2019 Dec;43(12):1471-1482.
(6)Zhang Yuxin; Wang Zhi; Xie Xiaona; Wang Jing; Wang Yingjian; Peng Qi sheng; Zhang Maolin; Wu Donglin; Liu Ning(*); Wang Hong bing(*); Sun Wan chun(*), Tatarinan N inhibits osteoclast differentiation through attenuating NF-kappa B, MAPKs and Ca2+-dependent signaling, International Immunopharmacology, 2018.12, 65: 199~211  
(7)Cao, Jinjin; Lu, Qiang; Liu, Ning(#); Zhang, Yu-Xin; Wang, Jing; Zhang, Maolin; Wang, Hong-Bing(*); Sun, Wan-Chun(*), Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents bone loss in LPS-treated mice.,International Immunopharmacology, 2017.5.30, 49: 109~117    
(8)Xu, Xiaohan; Liu, Ning; Wang, Yingjian; Pan, Lei-chang; Wu, Donglin; Peng, Qisheng; Zhang, Maolin; Wang, Hong-bing(*); Sun, Wan-chun(*), Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1. Int Immunopharmacol, 2016.5.01, 34: 212~219    
(9)Quan, Gui-Hua; Wang, Hongbing; Cao, Jinjin; Zhang, Yuxin; Wu, Donglin; Peng, Qisheng; Liu, Ning(*); Sun, Wan-Chun, Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-kappaB. Int J Mol Sci, 2015.12.10, 16(12): 29496~29507    
(10)Wang, Yingjian; Xu, Xiaohan; Wang, Hong-bing; Wu, Donglin; Li, Xiao-ou; Peng, Qisheng; Liu, Ning(*); Sun, Wan-chun(*), 17-Hydroxy-jolkinolide A inhibits osteoclast differentiation through suppressing the activation of NF-kappaB and MAPKs. Int Immunopharmacol, 2015.12.01, 29(2): 513~520
(11)Xu, Xiaohan; Liu, Ning; Zhang, Yu-Xin; Cao, Jinjin; Wu, Donglin; Peng, Qisheng; Wang, Hong-Bing(*); Sun, Wan-Chun(*), The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice. Molecules, 2016.1.11, 21(1): 77~77    
(12)Pan, Lei-Chang; Xu, Xiao-Han; Zhang, Na-Na; Liu, Ning; Wu, Dong-Lin; Wang, Yang; Peng, Qi-Sheng; Vandenplas, Michel; Wang, Hong-Bing(*); Sun, Wan-Chun(*), HJB-1, a 17-hydroxy-jolkinolide B derivative, inhibits LPS-induced inflammation in mouse peritoneal macrophages. Int Immunopharmacol, 2014.8.01, 21(2): 474~480    
(13)Chen, Wei; Zhang, Ying-Ying; Wang, Zhuo; Luo, Xiao-Hua; Sun, Wan-Chun(*); Wang, Hong-Bing(*), Phenolic derivatives from Radix Astragali and their anti-inflammatory activities. Nat Prod Commun, 2014.11.01, 9(11): 1577~1580