个人简介

主要研究方向

食源性寄生虫的致病机制、免疫逃逸机制及防控策略开发

主要学术成果

科研项目：   
（1）国家自然科学基金，青年基金，32302960，伪旋毛虫乙酰胆碱酯酶破坏肠道ILC2s的ChAT-ACh通路实现免疫逃逸的机制研究，2024.01-2026.12，30万元，在研，主持
（2）科技部，国家重点研发计划政府间国际科技创新合作项目，2022YFE0114600，MEmE食品链包虫病多个中心检测方法研发（子课题），2022.09-2025.08,90万元，在研，主持
（3）吉林省自然科学基金，青年成长科技计划项目，20220508052RC，Ts-HRG-1参与旋毛虫血红素运输的生物学功能研究，2022-01至2023-12，10万元，在研，主持
（4）吉林省科技厅，自然科学基金（联合基金项目），YDZJ202101ZYTS053，旋毛虫成虫期特异性蛋白对肠黏膜屏障的保护作用及其机制研究，2021-01至2023-12，8万元，在研，主持
（5）吉林省教育厅，一般项目，JJKH20231200KJ，伪旋毛虫乙酰胆碱酯酶破坏肠道ILC2s的ChAT-ACh通路实现免疫逃逸的机制研究，2022-01至2023-12，2.5万元，在研，主持
（6）横向项目，旋毛虫三种ES抗原蛋白的制备，2019.09-2022.07，90万元，已结题，主持

学术论文：   
[1] Jin X, Liu X, Ding J, Zhang L, Yang Y, Wang X, Yang Y, Liu M. Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner. PLoS Negl Trop Dis. 2020 Sep 25;14(9):e0008632.
[2] Ding J, Liu X, Bai X, Wang Y, Li J, Wang C, Li S, Liu M, Wang X. Trichinella spiralis: inflammation modulator. J Helminthol. 2020 Sep 21;94:e193.
[3] Ding J, Liu X, Tang B, Bai X, Wang Y, Li S, Li J, Liu M, Wang X. Murine hepatoma treatment with mature dendritic cells stimulated by Trichinella spiralis excretory/secretory products. Parasite. 2020;27:47. doi: 10.1051/parasite/2020045. Epub 2020 Jul 21.
[4] Pang J, Ding J, Zhang L, Zhang Y, Yang Y, Bai X, Liu X, Jin X, Guo H, Yang Y, Liu M. Effect of recombinant serine protease from adult stage of Trichinella spiralis on TNBS-induced experimental colitis in mice. Int Immunopharmacol. 2020 Sep;86:106699.
[5] Jin X, Yang Y, Ding J, Liu X, Shi H, Luo X, Jia W, Cai X, Vallee I, Boireau P, Bai X, Liu M. Nod-like receptor pyrin domain containing 3 plays a key role in the development of Th2 cell-mediated host defenses against Trichinella spiralis infection. Vet Parasitol. 2021 Sep;297:109159.
[6] Li J, Liu X, Ding J, Tang B, Bai X, Wang Y, Li S, Liu M, Wang X. Effect of Trichinella spp. or derived antigens on chemically induced inflammatory bowel disease (IBD) in mouse models: A systematic review and meta-analysis. Int Immunopharmacol. 2020 Aug;85:106646.
[7] Wang N, Bai X, Ding J, Lin J, Zhu H, Luo X, Fu Z, Zhu C, Jia H, Liu M, Liu X. Trichinella infectivity and antibody response in experimentally infected pigs. Vet Parasitol. 2021 Sep;297:109111. doi: 10.1016/j.vetpar.2020.109111. Epub 2020 Apr 18. PMID: 32334888.
[8] Ding J, Tang B, Liu X, Bai X, Wang Y, Li S, Li J, Liu M, Wang X. Excretory-secretory product of Trichinella spiralis inhibits tumor cell growth by regulating the immune response and inducing apoptosis. Acta Trop. 2022 Jan;225:106172.
[9] Li J, Ding J, Liu XL, Tang B, Bai X, Wang Y, Qiao WD, Liu MY, Wang XL. Upconverting phosphor technology-based lateral flow assay for the rapid and sensitive detection of anti-Trichinella spiralis IgG antibodies in pig serum. Parasit Vectors. 2021 Sep 22;14(1):487.
[10] Wang X, Li A, Wang R, Hou T, Chen H, Wang J, Liu M, Li C, Ding J. Lateral flow immunoassay strips based on europium(III) chelate microparticle for the rapid and sensitive detection of Trichinella spiralis infection in whole blood samples of pigs. Front Cell Infect Microbiol. 2022 Aug 9;12:955974.
[11] Li J, Ding J, Liu X, Tang B, Bai X, Wang Y, Li S, Wang X. Label-free serum detection of Trichinella spiralis using surface-enhanced Raman spectroscopy combined with multivariate analysis. Acta Trop. 2020 Mar;203:105314.
[12] Wang J, Jin X, Li C, Chen X, Li Y, Liu M, Liu X, Ding J. In vitro knockdown of TsDNase II-7 suppresses Trichinella spiralis invasion into the host's intestinal epithelial cells. PLoS Negl Trop Dis. 2023 Jun 8;17(6):e0011323.
[13] Ding J, Bai X, Wang X, Shi H, Cai X, Luo X, Liu M, Liu X. Immune Cell Responses and Cytokine Profile in Intestines of Mice Infected with Trichinella spiralis. Front Microbiol. 2017 Oct 31;8:2069.
[14] Ding J, Bai X, Wang XL, Wang YF, Shi HN, Rosenthal B, Boireau P, Wu XP, Liu MY, Liu XL. Developmental profile of select immune cells in mice infected with Trichinella spiralis during the intestinal phase. Vet Parasitol. 2016 Nov 15;231:77-82.