张楠

吉林大学人兽共患病研究所副教授,博士生导师

    职务 主讲人
    时间 地点
    主要研究方向 寄生虫感染与肿瘤关系、细胞极性建立与管腔形态发生 主要学术成果 科研项目:   
    (1) 一种潜在的人兽共患人五毛滴虫对小鼠肠道致病性研究(编号:32102696),国家自然科学基金青年基金项目,30万,主持,在研,2022.01.01至2024.12.31。
    (2) 秀丽线虫RAB-11互作蛋白筛选及其在上皮细胞极性建立中的作用研究(编号:20190103075JH),吉林省科技厅优秀青年人才基金项目,7万元,主持,结题,2019.01.01至2020.12.31。
    (3) 捕食线虫真菌次级代谢产物抗鸡球虫活性物质的研制(编号: 20230202084NC),吉林省科技厅重点研发项目,50万,主持,在研,2023.01.01-2025.12.31。
    (4) LEC-5与RAB-11互作在秀丽线虫肠上皮细胞极性中的作用(编号:2019M651196),中国博士后科学基金面上项目,8万元,主持,结题,2019-05至2020-12。
    (5) 基于标准物质研制的实验动物质量评价关键技术研究(编号:2021YFF0702900),国家重点研发计划青年科学家项目子课题,100万,子课题负责人,在研,2021.12-2024.11。
    (6) 隐孢子虫快速检测、治疗与载体疫苗构建(编号:2017YFD0501305),国家重点研发计划项目子课题,30万,子课题负责人,结题,2019.08-2020.12。
    (7) 宿主抗寄生虫感染先天免疫信号转导通路(编号:2015CB150306),国家重点基础研究发展计划(973计划)课题,609万,参加,结题,2015.01-2019.12。
    (8) 羊肝片吸虫病早期诊断双抗夹心ELISA和胶体金检测试剂盒的研制及其应用(编号:20200402044NC),吉林省科技厅科技发展计划项目,50万元,参加,结题,2020.01-2022.12。
    (9) 鸡球虫四价重组亚单位疫苗的研制(编号:20190301089NY),吉林省科技厅科技发展计划项目,50万元,参加,结题,2019.01-2021.12。


    学术论文:    近五年代表性学术论文:
    (1) Nan Zhang, Hongjie Zhang, Liakot A. Khan, Gholamali Jafari, Yong Eun, Edward Membreno, and Verena Gobel (*). The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity. Science Advances. 2023, 9(26). doi:10.1126/sciadv.ade4620. (吉林大学C类期刊,中科院1区,IF=13.6,封面文章)
    (2) Taotao Yue (#), Xichen Zhang (#), Pengtao Gong (#), Jianhua Li, Xiaocen Wang, Xin Li, Yeting Ma, Xuejiao Chen, Xu Zhang, Shuqin Cheng, Hongbo Zhang, Nan Zhang (*). Antitumor effect of invasive Lactobacillus plantarum delivering associated antigen gene sHSP between Trichinella spiralis and Lewis lung cancer cells. Int Immunopharmacol. 2023, 115:109708. doi: 10.1016/j.intimp.2023.109708. (中科院2区,IF=5.6)
    (3) Hongbo Zhang (#), Chunyan Zhao (#), Xichen Zhang (#), Jianhua Li, Pengtao Gong, Xiaocen Wang, Xin Li, Xin Wang, Xu Zhang, Shuqin Cheng, Taotao Yue and Nan Zhang (*). A potential role for Giardia chaperone protein GdDnaJ in regulating Giardia proliferation and Giardiavirus replication. Parasit Vectors, 2023,16(1):168. doi: 10.1186/s13071-023-05787-0. (中科院1区,IF=3.2)
    (4) Zhiteng Zhao (#), Xin Li (#), Nan Zhang (#), Jianhua Li, Na Zhao, Mengyao Gao, Xichen Zhang, Xiaocen Wang, Panpan Zhao, Lu Li, Min Sun, Lili Cao (*), Pengtao Gong (*). Multiple Regulations of Parasitic Protozoan Viruses: A Double-Edged Sword for Protozoa. mBio, 2023, 14(1):e0264222. doi: 10.1128/mbio.02642-22. (中科院1区,IF=6.4)
    (5) Hongbo Zhang (#), Yanhui Yu (#), Jianhua Li, Pengtao Gong, Xiaocen Wang, Xin Li, Yidan Cheng, Xiuyan Yu, Nan Zhang (*) and Xichen Zhang (*). Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection. Frontiers in Cellular and Infection Microbiology, 2022, 12:961974. doi: 10.3389/fcimb.2022.961974. (中科院2区,IF=5.7)
    (6) Hongbo Zhang (#), Nan Zhang (#), Pengtao Gong, Shuqin Cheng, Xiaocen Wang, Xin Li, Zhijun Hou, Chang Liu, Tianqi Bi, Bobo Wang, Yidan Cheng, Jianhua Li (*) and Xichen Zhang (*). Prevalence and molecular characterization of Pentatrichomonas hominis in Siberian tigers (Panthera tigris altaica) in northeast China. Integrative Zoology, 2022, 17: 543–549. (中科院1区,IF=3.3)
    (7) Taotao Yue (#), Nan Zhang (#), Jianhua Li, Xiangyun Lu, Xiaocen Wang, Xin Li, Hongbo Zhang, Shuqin Cheng, Bobo Wang, Pengtao Gong (*) and Xichen Zhang (*). Anti-osteosarcoma effectof antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis. Parasit Vectors, 2021, 14(1):498. doi: 10.1186/s13071-021-05008-6. (中科院1区,IF=3.2)
    (8) Shan Li (#), Nan Zhang (#), Shaoxiong Liu, Jianhua Li, Li Liu, Xiaocen Wang, Xin Li, Pengtao Gong (*) and Xichen Zhang (*). Protective Immunity Against Neospora caninum Infection Induced by 14-3-3 Protein in Mice. Front Vet Sci, 2021, 8:638173. doi: 10.3389/fvets.2021.638173. (中科院2区,IF=3.2)
    (9) Jingquan Dong (#), Nan Zhang (#), Panpan Zhao (#), Jianhua Li, Lili Cao, Xiaocen Wang, Xin Li, Ju Yang, Xichen Zhang (*) and Pengtao Gong (*). Disruption of Dense Granular Protein 2 (GRA2) Decreases the Virulence of Neospora caninum. Front Vet Sci, 2021, 8:634612. doi: 10.3389/fvets.2021.634612. (中科院2区,IF=3.2)
    (10) Nan Zhang (#), Hongbo Zhang (#), Yanhui Yu, Pengtao Gong, Jianhua Li, Ziyi Li, Ting Li, Zhanjie Cong, Chunying Tian, Xiaofeng Liu, Xiuyan Yu (*) and Xichen Zhang (*). High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients. Parasit & Vectors. 2019, 12(1):423. doi: 10.1186/s13071-019-3684-4. (中科院1区,IF=3.2)

    介绍 吉林大学人兽共患病研究所副教授,博士生导师
  • 个人简介

    教育经历:

    2010/09-2017/06,吉林大学,生命科学学院,生物化学与分子生物学专业,博士(硕博连读)

    2013/09-2015/09,美国哈佛医学院麻省总医院,生物化学与分子生物学专业,博士(联合培养)

    2006/09-2010/06,吉林大学,生物与农业工程学院,生物工程专业,本科

    工作经历:

    2021/09-至今,吉林大学,人兽共患病研究所,副教授

    2018/05-2021/08,吉林大学,人兽共患病研究所,讲师

    2018/05-2021/05,吉林大学,第一医院,博士后

    著作教材:

    《防生医学》,科学技术文献出版社,2023.10,参编。

    《动物寄生虫病学》,科学出版社,2023.12,副主编。

    获奖情况:

    4种原虫病毒的分离鉴定、全基因组的破译及转染原虫载体的构建,吉林省自然科学奖二等奖,吉林省科学技术奖励委员会,2019.10.23。(5/8

    社会兼职:

    吉林省寄生虫学会理事


  • 主要研究方向

    寄生虫感染与肿瘤关系、细胞极性建立与管腔形态发生

  • 主要学术成果

    科研项目:   
    (1) 一种潜在的人兽共患人五毛滴虫对小鼠肠道致病性研究(编号:32102696),国家自然科学基金青年基金项目,30万,主持,在研,2022.01.01至2024.12.31。
    (2) 秀丽线虫RAB-11互作蛋白筛选及其在上皮细胞极性建立中的作用研究(编号:20190103075JH),吉林省科技厅优秀青年人才基金项目,7万元,主持,结题,2019.01.01至2020.12.31。
    (3) 捕食线虫真菌次级代谢产物抗鸡球虫活性物质的研制(编号: 20230202084NC),吉林省科技厅重点研发项目,50万,主持,在研,2023.01.01-2025.12.31。
    (4) LEC-5与RAB-11互作在秀丽线虫肠上皮细胞极性中的作用(编号:2019M651196),中国博士后科学基金面上项目,8万元,主持,结题,2019-05至2020-12。
    (5) 基于标准物质研制的实验动物质量评价关键技术研究(编号:2021YFF0702900),国家重点研发计划青年科学家项目子课题,100万,子课题负责人,在研,2021.12-2024.11。
    (6) 隐孢子虫快速检测、治疗与载体疫苗构建(编号:2017YFD0501305),国家重点研发计划项目子课题,30万,子课题负责人,结题,2019.08-2020.12。
    (7) 宿主抗寄生虫感染先天免疫信号转导通路(编号:2015CB150306),国家重点基础研究发展计划(973计划)课题,609万,参加,结题,2015.01-2019.12。
    (8) 羊肝片吸虫病早期诊断双抗夹心ELISA和胶体金检测试剂盒的研制及其应用(编号:20200402044NC),吉林省科技厅科技发展计划项目,50万元,参加,结题,2020.01-2022.12。
    (9) 鸡球虫四价重组亚单位疫苗的研制(编号:20190301089NY),吉林省科技厅科技发展计划项目,50万元,参加,结题,2019.01-2021.12。


    学术论文:    近五年代表性学术论文:
    (1) Nan Zhang, Hongjie Zhang, Liakot A. Khan, Gholamali Jafari, Yong Eun, Edward Membreno, and Verena Gobel (*). The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity. Science Advances. 2023, 9(26). doi:10.1126/sciadv.ade4620. (吉林大学C类期刊,中科院1区,IF=13.6,封面文章)
    (2) Taotao Yue (#), Xichen Zhang (#), Pengtao Gong (#), Jianhua Li, Xiaocen Wang, Xin Li, Yeting Ma, Xuejiao Chen, Xu Zhang, Shuqin Cheng, Hongbo Zhang, Nan Zhang (*). Antitumor effect of invasive Lactobacillus plantarum delivering associated antigen gene sHSP between Trichinella spiralis and Lewis lung cancer cells. Int Immunopharmacol. 2023, 115:109708. doi: 10.1016/j.intimp.2023.109708. (中科院2区,IF=5.6)
    (3) Hongbo Zhang (#), Chunyan Zhao (#), Xichen Zhang (#), Jianhua Li, Pengtao Gong, Xiaocen Wang, Xin Li, Xin Wang, Xu Zhang, Shuqin Cheng, Taotao Yue and Nan Zhang (*). A potential role for Giardia chaperone protein GdDnaJ in regulating Giardia proliferation and Giardiavirus replication. Parasit Vectors, 2023,16(1):168. doi: 10.1186/s13071-023-05787-0. (中科院1区,IF=3.2)
    (4) Zhiteng Zhao (#), Xin Li (#), Nan Zhang (#), Jianhua Li, Na Zhao, Mengyao Gao, Xichen Zhang, Xiaocen Wang, Panpan Zhao, Lu Li, Min Sun, Lili Cao (*), Pengtao Gong (*). Multiple Regulations of Parasitic Protozoan Viruses: A Double-Edged Sword for Protozoa. mBio, 2023, 14(1):e0264222. doi: 10.1128/mbio.02642-22. (中科院1区,IF=6.4)
    (5) Hongbo Zhang (#), Yanhui Yu (#), Jianhua Li, Pengtao Gong, Xiaocen Wang, Xin Li, Yidan Cheng, Xiuyan Yu, Nan Zhang (*) and Xichen Zhang (*). Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection. Frontiers in Cellular and Infection Microbiology, 2022, 12:961974. doi: 10.3389/fcimb.2022.961974. (中科院2区,IF=5.7)
    (6) Hongbo Zhang (#), Nan Zhang (#), Pengtao Gong, Shuqin Cheng, Xiaocen Wang, Xin Li, Zhijun Hou, Chang Liu, Tianqi Bi, Bobo Wang, Yidan Cheng, Jianhua Li (*) and Xichen Zhang (*). Prevalence and molecular characterization of Pentatrichomonas hominis in Siberian tigers (Panthera tigris altaica) in northeast China. Integrative Zoology, 2022, 17: 543–549. (中科院1区,IF=3.3)
    (7) Taotao Yue (#), Nan Zhang (#), Jianhua Li, Xiangyun Lu, Xiaocen Wang, Xin Li, Hongbo Zhang, Shuqin Cheng, Bobo Wang, Pengtao Gong (*) and Xichen Zhang (*). Anti-osteosarcoma effectof antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis. Parasit Vectors, 2021, 14(1):498. doi: 10.1186/s13071-021-05008-6. (中科院1区,IF=3.2)
    (8) Shan Li (#), Nan Zhang (#), Shaoxiong Liu, Jianhua Li, Li Liu, Xiaocen Wang, Xin Li, Pengtao Gong (*) and Xichen Zhang (*). Protective Immunity Against Neospora caninum Infection Induced by 14-3-3 Protein in Mice. Front Vet Sci, 2021, 8:638173. doi: 10.3389/fvets.2021.638173. (中科院2区,IF=3.2)
    (9) Jingquan Dong (#), Nan Zhang (#), Panpan Zhao (#), Jianhua Li, Lili Cao, Xiaocen Wang, Xin Li, Ju Yang, Xichen Zhang (*) and Pengtao Gong (*). Disruption of Dense Granular Protein 2 (GRA2) Decreases the Virulence of Neospora caninum. Front Vet Sci, 2021, 8:634612. doi: 10.3389/fvets.2021.634612. (中科院2区,IF=3.2)
    (10) Nan Zhang (#), Hongbo Zhang (#), Yanhui Yu, Pengtao Gong, Jianhua Li, Ziyi Li, Ting Li, Zhanjie Cong, Chunying Tian, Xiaofeng Liu, Xiuyan Yu (*) and Xichen Zhang (*). High prevalence of Pentatrichomonas hominis infection in gastrointestinal cancer patients. Parasit & Vectors. 2019, 12(1):423. doi: 10.1186/s13071-019-3684-4. (中科院1区,IF=3.2)