个人简介

主要研究方向

分子病毒学

主要学术成果

科研项目：   
1、国家自然科学基金面上项目：猪圆环病毒2b/2d亚型优势中和表位鉴定及嵌合病毒样颗粒免疫原性研究，57万员；
2、横向课题：圆环病毒基因工程疫苗和口蹄疫基因工程疫苗的后续开发，1080万元；

学术论文：   
1.    Bi, M., X. Li, W. Zhai, B. Yin, K. Tian and X. Mo (2020). "Structural insight into the type-specific epitope of porcine circovirus type 3." Bioscience Reports 40(6). (Corresponding author)
2.    Mo X*, Li X, Deng J, Yin B, Tian K* and Yuan YA (2019) Structural mechanism of virus-like-particle assembly of PCV2 capsid protein and identification of PCV2 type-specific epitope. PLoS Pathogens 15(3): e1007562. https://doi. org/10.1371/journal.ppat.1007562. (co-corresponding author)
3.    X Ju, X Xu, M Shen, X Mo, H Fan and L Li (2020). “Biochemical and structural insights into an Ochrobactrum sp. CSL1 ribose-5-phosphate isomerase A and its roles in isomerization of rare sugars.” Enzyme and Microbial Technology., October 2020, 140, 109604  
4.    Mo X, Yang X, Yuan YA (2018) Structural insights into Drosophila-C3PO complex assembly and 'Dynamic Side Port' model in substrate entry and release. Nucleic Acids Research. 46:8590-8604.
5.    Xi X1, Mo X1, Xiao Y, Yin B, Lv C, et al. (2016) Production of Escherichia coli-based virus-like particle vaccine against porcine circovirus type 2 challenge in piglets: Structure characterization and protective efficacy validation. J Biotechnol 223: 8-12. (1co-first author).
6.    Zhang TY, Chen HY, Cao JL, Xiong HL, Mo XB, et al. (2019) Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction. Nature Communications 10: 3192.
7.    Wei M, Wang D, Li Z, Song S, Kong X, Mo X, Yang Y, He M, Li Z, Huang B, Lin Z, Pan H, Zheng Q, Yu H, Gu Y, Zhang J, Li S, Xia N. 2018. N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro. Emerging microbes & infections 7:160.
8.    Zheng Z, Paul SS, Mo X, Yuan YA, Tan YJ (2018) The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis. Vaccines (Basel) 6.
9.    Zhang, T. Y. Yuan, Q. Zhao, J. H. Zhang, Y. L. Yuan, L. Z. Lan, Y. Lo, Y. C. Sun, C. P. Wu, C. R. Zhang, J. F. Zhang, Y. Cao, J. L. Guo, X. R. Liu, X. Mo, X. B. Luo, W. X. Cheng, T. Chen, Y. X. Tao, M. H. Shih, J. W. Zhao, Q. J. Zhang, J. Chen, P. J. Yuan, Y. A. Xia, N. S. (2016) Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen. Gut 65: 658-671.
10.    Xiao, Y., H. Y. Chen, Y. Wang, B. Yin, C. Lv, X. Mo, H. Yan, Y. Xuan, Y. Huang, W. Pang, X. Li, Y. A. Yuan and K. Tian (2016) Large-scale production of foot-and-mouth disease virus (serotype Asia1) VLP vaccine in Escherichia coli and protection potency evaluation in cattle. BMC Biotechnol 16: 56.

专利：
1.    Li S, Mo X, Wei M, Pan H, Zhang J, Xia N. (2012) Truncated L1 Protein of Human Papillomavirus Type 52. A61K39/12; A61P31/20; C07K14/025; C12N1/21; C12N15/70 ed (PCT International Patent Application). 国际专利
2.    田克恭，袁于人，孙进忠，莫小兵，张许科 （2017）一种疫苗组合物及其制备方法CN104623653B
3.    李少伟，莫小兵，魏旻希，潘晖榕，张军，夏宁邵 （2017）截短的人乳头瘤病毒52型L1蛋白 CN102268076B
4.    袁于人，莫小兵 （2014）截短的PCV2型衣壳蛋白ORF2病毒样颗粒及其制备方法 CN104017813A
5.    袁于人，莫小兵 （2013）大肠杆菌来源的PCV2 ORF2衣壳蛋白病毒样颗粒的制备 CN103173470A
6.    田克恭，袁于人，李向东，殷波，肖燕，陆洲，胡冬学，孙进忠，莫小兵，张许科 （2018）一种猪圆环病毒3型免疫原性组合物、制备方法和应用WO2018196836A1
7.    田克恭，袁于人，李向东，殷波，肖燕，陆洲，胡冬学，孙进忠，莫小兵，张许科（2018）一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用 WO2018233264A1