个人简介

主要研究方向

动物检验检疫（动物疫病的快速诊断与防治）、病毒致病机理、病毒变异与进化

主要学术成果

科研项目：   
1. 国家自然科学基金  E种肠道病毒小鼠感染模型及病毒准种与异质性（项目编号：31572531）2016.1-2019.12
2. 国家十三五重点研发计划项目 “牛羊重要疫病诊断与检测新技术研究”（项目编号：2016YFD0500904）2016.6-2020.12
3. 国家十三五重点研发计划项目 “畜禽重要疫病的微生物组及新发病毒的病原生态学研究”（项目编号：2017YFD0500104）2017.6-2020.12
4. 吉林省横向项目“牛病毒性腹泻的诊断与净化”（项目编号：2021XQ0010）2021.05-2022.12
5. 吉林省科技重点攻关课题  吉林省新发牛肠道病毒感染诊断与流行病学研究  2014.1-2016.12  
6. 国家自然科学基金  牛病毒性腹泻病毒不同生物型的分子差异（项目编号：39570545）1996.1-1998.12
7. 农业部九五重点课题   牛病毒性腹泻病毒感染猪的研究  1996.1-1999.12
8. 吉林省科委  牛病毒性腹泻病毒多生物型疫苗的研究（项目编号：960204-4）1996.1-2000.12
9. 吉林省科委 双抗体夹心ELISA检测牛粘膜病病毒及粘膜病病牛场净化研究（项目编号：917048） 1991.1-1994.12
10. 农牧大学校长基金  牛病毒性腹泻病毒的致病机理（项目编号：NM 97-03）1997.1-1999.12
学术论文：    发表代表性文章
1. Zhang Q, Zhang F, Chang X, et al. A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism. Viruses. 2023;15(2).
2. Chang X, Lin Q, Zhang Q, et al. Molecular Analysis of Caprine Enterovirus Circulating in China during 2016-2021: Evolutionary Significance. Viruses, 2022. 14(5).
3. Chang XR,  Zhu LS, Hu JY, et al. Unveiling of Evolution Pattern for HY12 Enterovirus Quasispecies and Pathogenicity Alteration. Viruses, 2021. 13(11).
4. He J, Yang LP, Chang PX, et al. Zika virus NS2A protein induces the degradation of KPNA2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy. Autophagy. 2020;16(12):2238-51.
5. Chang X, Lin Q, Hu J, et al. Discovery of a virus of the species Enterovirus F in goats. Archives of virology 2019, 164, 2551-2558.
6. Liu D, Hu J, Dong H, et al. Identification of three linear B cell epitopes using monoclonal antibodies against bovine enterovirus VP2 protein. Applied microbiology and biotechnology 2019, 103, 7467-7480.
7. Li X, Zhang Z, Chang X, et al. Disruption of blood-brain barrier by an Escherichia coli isolated from canine septicemia and meningoencephalitis. Comparative immunology, microbiology and infectious diseases 2019;63:44-50.
8. Liu D, Liu CM, Hu JY, et al. Construction and evaluation of HA-epitope-tag introduction onto the VP1 structural protein of a novel HY12 enterovirus. Virology 2018;525:106-116.
9. Wang M, He J, Lu H, et al. A novel enterovirus species identified from severe diarrheal goats. PloS one 2017;12(4):e0174600.
10. Zhu L, Lu H, Cao Y, et al. Molecular Characterization of a Novel Bovine Viral Diarrhea Virus Isolate SD-15. PloS one 2016;11(10):e0165044.
11. Zhu LS, Xing ZL, Gai XC, et al. Identification of a Novel Enterovirus E Isolates HY12 from Cattle with Severe Respiratory and Enteric Diseases. PloS one 2014;9(5).
12. Wang XP, Zhang YJ, Deng JH, et al. Characterization of the promoter region of the viral interferon regulatory factor encoded by Kaposi's sarcoma-associated herpesvirus. Oncogene 2001;20(4):523-530.
13. Wang XP, Zhang YJ, Deng JH, et al. Transcriptional regulation of Kaposi's sarcoma-associated herpesvirus-encoded oncogene viral interferon regulatory factor by a novel transcriptional silencer, Tis. J Biol Chem 2002;277(14):12023-12031.
14.  王新平,涂长春,李红卫,金扩世,宣华,常国权,孙红梅,朱维正,费恩阁,殷震.从疑似猪瘟病料中检出牛病毒性腹泻病毒[J].中国兽医学报,1996(04):30-34.