个人简介

主要研究方向

动物性食品安全

主要学术成果

科研项目：   
1.    长春市科技局科技发展计划科技攻关项目：21ZGN34，红肉新型内源危害因子Neu5Gc快速检测技术开发，2021.11-2023.10，项目经费：50万元，主持，在研
2.    国家自然科学基金面上项目：基于双功能抗原模拟肽偶合物诱导B细胞无能对红肉中Neu5Gc介导的慢性炎症的影响（32072943）， 2021.01-2024.12，项目经费：58万元，主持，在研
3.    吉林省科技发展计划重点研发项目：冷链肉品重要致病性嗜冷菌SHERLOCK检测技术的开发与应用（20210203036SF），2021.07-2024.06，项目经费：30万元，主持，在研
4.    国家重点研发计划子课题：牛羊养殖、屠宰和牛奶生产过程中重要食源性病原微生物的流行与传播规律研究， 2018.06-2021.06，项目经费：45万元，结题
5.    国家重点研发计划子课题：基于组学的食源性病原微生物快速高通量检测技术—OA检测技术研发， 2017.06-2021.12，项目经费：26万元，结题
6.    横向合作课题：藻类保健品污染毒素快速检测新型抗体开发（2015220101000658），2015.06-2020.6，项目经费：50万元，主持，结题
7.    横向合作课题藻：河豚毒素活性阻断功能抗体开发（2015220101000657），2015.06-2017.  12, 项目经费：20万元，主持，结题
学术论文：    发表论文:
1.    Yiran Xiao1, Honglin Ren1, Han Wang, Deying Zou, Yixin Liu, Haosong Li, Pan Hu, Yansong Li, Zengshan Liu, Shiying Lu*. A rapid and inexpensive nucleic acid detection platform for Listeria monocytogenes based on the CRISPR/Cas12a system. Talanta,259 (2023) 124558 (2022IF 6.556)
2.    Zhanxu Liu, Nanya Wang, Zhaoli Meng, Shiying Lu*, Gong Peng*. Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma. Toxicology, Volume 493, July 2023, 153556. https://doi.org/10.1016/j.tox.2023.153556. (2022 IF4.571)
3.    Yiran Xiao#, Honglin Ren#, Pan Hu, Yang Wang, Han Wang, Yansong Li, Kai Feng, Cong Wang, Qi Cao, Yuxi Guo, Zengshan Liu, Shiying Lu*. Ultra-Sensitive and Rapid Detection of Pathogenic Yersinia enterocolitica Based on the CRISPR/Cas12a Nucleic Acid Identification Platform, Foods, 2022, 11(14): 2160-2160 (2021 IF 5.5612 )
4.    Hailing Zhang1,2, Dongliang Zhang2, Han Lu2, Deying Zou1, Bo Hu2, Shizhen Lian2 and Shiying Lu1*. Antiviral activity of minkinterferon alpha expressed in the yeast Pichia pastoris. Frontiers in Veterinary Science, 2022,09.14.DOI 10.3389/fvets.2022.976347(2021 IF 3.471)
5.    Xun Guo1, Jiang Chang1, Shiying Lu1, Pan Hu1, Deying Zou, Yansong Li, Feng Li, Jishan Liu, Qi Cao, Kai Zhang, Junpeng Zhan, Yixin Liu, Xin Yang, Honglin Ren*. Multiantigen epitope fusion recombinant proteins from capsids of serotype 4 fowl adenovirus induce chicken immunity against avian Ankara disease, Veterinary Microbiology, 2023, 278(2023): 109661 (2022IF 3.246)
6.     Deying Zoua,b,1, Jiang Chang a,1, Shiying Lua,1, Jianfeng Xub,1, Pan Hua, Kai Zhanga, Xiaoli Sunb, Wei Guob, Yansong Lia, Zengshan Liua, Honglin Rena*.Analysis of virulence proteins in pathogenic Acinetobacter baumannii to provide early warning of zoonotic risk. Microbiological Research 266 (2023) 127222（2022 IF 5.070）
7.    Han Wang1, Hong Lin Ren1, Pan Hu1, Yan Song Li, Yu Zheng, Qi Cao, Zhan Xu Liu, Zeng Shan Liu, Yong Yang, Shi Ying Lu*. A Fluorescence Immunochromatographic Strip Based on Quantum Dot Nanobeads for the Rapid Detection of Okadaic Acid. Food Analytical Methods. 2022,15 (9), pp.2470-2478 (2021 IF 3.366)
8.    Qiang Zhao#, Pan Hu#, Qianqian Li, Shasha Zhang, Hanxiao Li, Jiang Chang, Qiujie Jiang, Yu Zheng, Yansong Li, Zengshan Liu, Honglin Ren* & Shiying Lu*. Prevalence and transmission characteristics of Listeria species from ruminants in farm and slaughtering environments in China. Emerging Microbes & Infections, 2021,10:356-364 （2021 IF 19.568）
9.    Yonghong Zha#, Shiying Lu#, Pan Hu, Honglin Ren, Zengshan Liu, Weihua Gao, Chengmin Zhao, Yansong Li* and Yu Zhou*. Dual-Modal Immunosensor with Functionalized Gold Nanoparticles for Ultrasensitive Detection of Chloroacetamide Herbicides. ACS Applied Materials & Interfaces, 2021, 13, 6091−6098（2021 IF10.383）
10.    Yu Zheng#, Pan Hu#, Honglin Ren#, Han Wang, Qi Cao, Qiang Zhao, Hanxiao Li, Hailing Zhang, Zhanxu Liu, Yansong Li, Cong Wang, Zengshan Liu, Shiying Lu*.RPA-SYBR Green I based instrument-free visual detection for pathogenic Yersinia enterocolitica in meat,Analytical Biochemistry,621（2021）:1-6 （2021 IF 3.1908）
11.    Jiang Chang#, Xilin Liu#, Honglin Ren#, Shiying Lu#, Meng Li, Song Zhang, Ke Zhao, Hanxiao Li, Xiaoshi Zhou, Lixiong Peng, Zengshan Liu, Pan Hu. Pseudomonas Exotoxin A-Based Immunotherapy Targeting CCK2R-Expressing Colorectal Malignancies: An In Vitro and In Vivo Evaluation, Molecular Pharmaceutics, 2021,18: 2285-2297 (2021 IF 5.364)
12.    Shi-Jun Zhang#, Lu-Lu Wang#, Shi-Ying Lu #, Pan Hu, Yan-Song Li, Ying Zhang, Heng-Zhen Chang, Fei-Fei Zhai, Zeng-Shan Liu, Zhao-Hui Li, Hong-Lin Ren*. A novel, rapid, and simple PMA-qPCR method for detection and counting of viable Brucella organisms, J Vet Res 64, 253-261,2020 （2019 IF 1.039）
13.    Han Wanga1, Zong-Cheng Wuab1, Pan Hua1, Hong-Lin Rena1, Yan-Song Lia, Yu Zhenga, Cong Wanga, Zeng-Shan Liua, Shi-Ying Lua*. Identification of chicken-derived scFv against N-glycolylneuraminic acid retrieved from an immune library by phage display. Protein Expression and Purification, Volume 182, June 2021, 105841 （2021 IF2.0248）
14.     Hong Zhang#, Shi-Ying Lu#, Honglin Ren, Ke Zhao, Yansong Li, Yuting Guan, Hanxiao Li, Pan Hu* and Zengshan Liu*. Cytotoxicity and degradation product identification of thermally treated ceftiofur, RSC Adv., 2020, 10, 18407–18417（2019 IF 3.119）
15.    Hong Zhang#, Shi-Ying Lu#, Honglin Ren, Ke Zhao, Yansong Li, Yuting Guan, Hanxiao Li, Pan Hu* and Zengshan Liu*. Acute oral toxicity and acute intraperitoneal studies of thermally treated ceftiofur[J]. Chemical and Pharmaceutical Bulletin, 2020,68,1061-1068. （2019 IF 1.416）
16.    Shi-Jun Zhang#, Lu-Lu Wang#, Shi-Ying Lu#, Pan Hu, Yan-Song Li, Ying Zhang, Heng-Zhen Chang, Fei-Fei Zhai, Zeng-Shan Liu, Zhao-Hui Li, Hong-Lin Ren*. A novel, rapid, and simple PMA-qPCR method for detection and counting of viable Brucella organisms，J Vet Res 64, 253-261, 2020 （2019 IF 1.039）
17.    Shi-Jun Zhang1#, Xing Guo12#, Pan Hu1#, Shi-Ying Lu1#, Nan-Nan Liu1,Bao-Quan Fu3, Nan Wang4, Yan-Song Li1, Lu-Lu Wang1, Jiang Chang1,Heng-Zhen Chang1, Zeng-Shan Liu1, Yu Zhou1, and Hong-Lin Ren1*.Characterization of a Novel Interleukin-1 Receptor Antagonist from Sheep (Ovis aries). JOURNAL OF INTERFERON & CYTOKINE RESEARCH,40（5）:268-278,2020 （2019 IF 2.032）
18.    Lu-Lu Wang1†, Xiao-Feng Chen1†, Pan Hu1†, Shi-Ying Lu1†, Bao-Quan Fu2, Yan-Song Li1, Fei-Fei Zhai 1, Dan-Di Ju1, Shi-Jun Zhang1, Yi-Ming Shui1, Jiang Chang1, Xiao-Long Ma 1,3, Bing Su1, Yu Zhou1, Zeng-Shan Liu1 and Hong-Lin Ren1*. Host Prdx6 contributing to the intracellular survival of Brucella suis S2 strain, BMC Veterinary Research (2019) 15:304
19.    Lu-Lu Wang1#, Shi-Ying Lu1#, Pan Hu1,Bao-Quan Fu2, Yan-Song Li1, Fei-Fei Zhai1, Dan-Di Ju1,Shi-Jun Zhang1, Bing Su1, Yu Zhou1, Zeng-Shan Liu1, Hong-Lin Ren1.Construction and activity analyses of single functional mouse peroxiredoxin 6 (Prdx6), J Vet Res 63, 99-105, 2019（2018 IF 1.039）
20.    Sheng Gong1#, Honglin Ren1#, Chao Lin, Pan Hu, Ruiyun Tian, Zengshan Liu, Yansong Li, Yu Zhou,Yong Yang, Shiying Lu∗. Immunochromatographic strip biosensor for the rapid detection of N-glycolylneuraminic acid based on aptamer-conjugated nanoparticle. Analytical Biochemistry. 561–562 (2018) 52–58（2017 IF 2.275）
21.    Yi-Ming Shuia,1#, Shi-Ying Lua,1#, Xing Guoa,c, Xi-Lin Liua, Bao-Quan Fub, Pan Hua, Lin-Lin Qua, Nan-Nan Liua, Yan-Song Lia, Lu-Lu Wanga, Fei-Fei Zhaia, Dan-Di Jua, Zeng-Shan Liua, Yu Zhoua,Hong-Lin Rena,∗ Molecular characterization and differential expression analysis of interleukin 1β from Ovis aries, Microbial Pathogenesis , 2018,116: 180-188
22.    Yong-Jie Yang1,2#, Zeng-Shan Liu1, Shi-Ying Lu1#, Pan Hu1, Chuang Li2, Waqas Ahmad1,5, Yan-Song Li1, Yun-Ming Xu1,3, Feng Tang1,4, Yu Zhou1, Hong-Lin Ren1*, Cloning and differential expression analyses of Cdc42 from sheep, J Vet Res,2018,62, 113-119
23.    Pan Hu,†, Song Zhang,†, Shi-ying Lu†, Meng Li, Jiang Chang, Meng-yun Wang, Chang Li, Ke Zhao,Yu-Ting Guan,Yuan-Yuan Zhang, Yan-Song Li, Yu Zhou, Zeng-Shan Liu*, Ou Bai*and Hong-Lin Ren*. An efficient scheme for purification of a novel recombinant immunotoxin, rCCK8PE38, for anti-tumour experiments,Biomedical Chromatography: BMC,2018,32(6): e4197. (2017 IF 1.613)
专利;
1.    柳增善,任洪林,卢士英,周玉,孟宪梅,李岩松,李兆辉,于师宇,张俊辉,李研东,任立松,王颖,饶星.“食品污染物免疫学快速检测技术基础研究”吉林省科技进步二等奖，证书编号2010J20029,2010,12
2.    周 玉,李岩松,孟星宇,张娞媛,卢士英,胡 盼,任洪林,张俊辉,杨丽，柳增善,全国商业科技进步奖,一等奖，食品和水安全纳米生物探针的设计合成及快检体系构建,中国商业联合会,2017-1-25-R05,2017.12
3.    于 光,柳增善,卢士英,周 玉,李岩松,任洪林,张代辉,霍方珍.“大田软海绵酸免疫学检测技术研究”,吉林省出入境检验检疫局科技兴检三等奖.证书编号：2007-JL38-RO,2007
授权专利：    1.    卢士英、王 菡、王 洋、李岩松、任洪林、胡 盼、柳增善、杨勇、周  玉、曹 旗、郑 宇，一种腹泻性贝毒大田软海绵酸荧光检测试纸及其检测方法，国家发明专利,申请号: 201910330343.7，授权号：ZL 2019 1 0330343.7，授权公告号：CN 110018145 B，授权日2022.01.25
2.    卢士英，张 虹，柳增善，胡 盼，任洪林，李岩松，周 玉, 赵 柯，王 菡,一种头孢噻呋降解产物的制备方法, 国家发明专利,申请号: 201910904943.X, 专利号：ZL 2019 1 0904943.X，授权公告号： CN 110590698  B，授权日2021.11.16
3.    卢士英，郑宇，柳溪林，任洪林，胡 盼，柳增善，李岩松，赵强， 王菡，肖毅然，王聪，鉴定致病性小肠结肠炎耶尔森氏菌的特异性引物对、检测试剂盒及其应用, 申请爱理号202110397506.0，申请日2021.4.14
4.    卢士英, 肖毅然, 柳溪林, 任洪林, 胡盼, 李岩松, 王洋, 王菡, 王聪, 郭禹汐 , 一种致病性小肠结肠炎耶尔森氏菌检测用引物对和CRISPR/Cas12a检测试剂盒, 2022.05.31, 中国, CN202210607278.X
5.    卢士英、肖毅然、任洪林、李香荷、王菡、胡盼、李岩松、柳增善、王聪、郭禹汐.一种基于CRISPR/Cas12a检测单增李斯特菌的现场可视化试剂盒及应用，2022.9.8，中国，202211090936.9
6.    卢士英，李焓笑，柳溪林，胡 盼，任洪林，柳增善，李岩松，赵强，郑宇，常 江.一种基于SHERLOCK检测单增李斯特菌的现场可视化试剂盒及应用,发明专利,申请受理号202010846569.5，申请日2020.8.24
7.    卢士英,任洪林,李岩松,柳增善,周 玉,孟宪梅,李兆辉,于师宇,林 超,闫东明,王里奇,李 乐.一种海洋贝毒素单抗制备方法,国家发明专利,授权号:ZL201010153343.3，授权日：2016.8.03