个人简介

主要研究方向

细菌感染疾病药物靶标发现、新药筛选及相关剂型研究；新兽药开发及检测分析

主要学术成果

科研项目：   
1. 横向课题，多穗石柯提取物口服液的新兽药研制，3R1205874206，2020/10-2025/10，150.00万元，在研，负责人。
2. 横向课题，金霉素预混剂羊病原菌药敏试验和最佳适应症筛选，3R2220064206，2021/12-2022/03，35.00万元，已结题，负责人。
3. 吉林大学优秀青年教师培养计划， 2018/01-2021/12，18万
4. 国家自然科学基金青年基金项目，No. 31502117，槲皮素对金黄色葡萄球菌凝固酶的抑制作用及机制，2016/01-2018/12，20万，已结题，负责人。
5. 中国博士后科学基金特别资助，2015T80309，金黄色葡萄球菌分选酶SortaseB 抑制剂筛选及机制研究，2015/05-2016/10，15万元，已结题，负责人。
6. 中国博士后面上资助，2014M561301，咖啡酸对金葡菌分选酶SortaseA的抑制作用及机制，2014/09-2016/10，5万元，已结题，负责人。
7. 吉林省科技发展计划科技创新人才培育计划优秀青年人才基金项目，20180520043JH，绵马贯众素通过抑制vWbp蛋白治疗金葡菌感染的药效学评价及机制研究，2018/01-2019/12，10万，已结题，负责人。
学术论文：   
1. Shi L, Tianqi F, Zhang C, Deng X, Zhou Y, Wang J*, Wang L*. High-protein compound yogurt with quinoa improved clinical features and metabolism of high-fat diet-induced nonalcoholic fatty liver disease in mice. J Dairy Sci. 2023. 106(8):5309-5327.
2. Liu M#, Lv Q#, Xu J, Liu B, Zhou Y, Zhang S, Shen X*, Wang L*. Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro. Biochem Pharmacol. 2023. 209:115447.
3. Guan S#, Zhong L#, Yu H, Wang L, Jin Y, Liu J, Xiang H, Yu H*, Wang L*, Wang D*. Molecular docking and proteomics reveals the synergistic antibacterial mechanism of theaflavin with β-lactam antibiotics against MRSA. Front Microbiol. 2022. 13:993430.
4. Guan S#, Yu H#, Xiang H, Wang L, Liu J, Wu A, Zheng J, Dong H*, Wang L*,Wang D*. WYBQ-4: a New Bactericidal Agent against Methicillin-Resistant Staphylococcus aureus. Microbiol Spectr. 2022. 10(5):e0054722.
5. Li S, Xu X, Wei L, Wang L*, Lv Q*. Acacetin Alleviates Listeria monocytogenes Virulence Both In Vitro and In Vivo via the Inhibition of Listeriolysin O. Foodborne Pathog Dis. 2022. 19(2):115-125.
6. Jin Y#, Yang P#, Wang L#, Gao Z, Lv J, Cui Z, Wang T, Wang D*, Wang L*. Galangin as a direct inhibitor of vWbp protects mice from Staphylococcus aureus-induced pneumonia. J Cell Mol Med. 2022. 26(3):828-839.
7. Wang L#, Li Q#, Li J, Jing S, Jin Y, Yang L, Yu H, Wang D, Wang T, Wang L*. Eriodictyol as a Potential Candidate Inhibitor of Sortase A Protects Mice From Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia. Front Microbiol. 2021. 12:635710.
8. Wang L, Li B, Si X, Liu X, Deng X, Niu X, Jin Y, Wang D, Wang J. Quercetin protects rats from catheter‐related Staphylococcus aureus infections by inhibiting coagulase activity. J Cell Mol Med. 2019.
9. Mu D#, Luan Y#, Wang L#, Gao Z, Yang P, Jing S, Wang Y, Xiang H, Wang T*, Wang D*. The combination of salvianolic acid A with latamoxef completely protects mice against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus. Emerg Microbes Infect. 2020. 9(1):169-179.
10. Li B, Jin Y, Xiang H, Mu D, Yang P, Li X, Zhong L, Cao J, Xu D, Gong Q, Wang T, Wang L*, Wang D*. An Inhibitory effect of Dryocrassin ABBA on Staphylococcus aureus vWbp that Protects Mice from Pneumonia. Front Microbiol. 2019. 10:7.
11. Zhong X#, Xiang H#, Wang T#, Zhong L, Ming D, Nie L, Cao F, Li B, Cao J, Mu D, Ruan K, Wang L*, Wang D*. A novel inhibitor of the new antibiotic resistance protein OptrA. Chem Biol Drug Des. 2018 . 92(2):1458-67.
12. Ming D#, Wang D#, Cao F, Xiang H, Mu D, Cao J, Li B, Zhong L, Dong X, Zhong X, Wang L*, Wang T*. Kaempferol Inhibits the Primary Attachment Phase of Biofilm Formation in Staphylococcus aureus. Front Microbiol. 2017. 8:2263.
13. Zhao X, Liu B, Liu S, Wang L*, Wang J*. Anticytotoxin Effects of Amentoflavone to Pneumolysin. Biol Pharm Bull. 2017. 40(1):61-7.
14. Bi C, Dong X, Zhong X, Cai H, Wang D*, Wang L*. Acacetin Protects Mice from Staphylococcus aureus Bloodstream Infection by Inhibiting the Activity of Sortase A. Molecules. 2016. 21(10).
15. Bi C#, Wang L#, Niu X, Cai H, Zhong X, Deng X, Wang T*, Wang D*. The use of chlorogenic acid and its analogues as inhibitors: an investigation of the inhibition of sortase A of Staphylococcus aureus using molecular docking and dynamic simulation. Biotechnol Lett. 2016. 38(8):1341-7.
16. Wang L#, Bi C#, Cai H, Liu B, Zhong X, Deng X, Wang T, Xiang H, Niu X*, Wang D*. The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition. Front Microbiol. 2015. 6:1031.
17. Wang L#, Bi C#, Wang T, Xiang H, Chen F, Hu J, Liu B, Cai H, Zhong X, Deng X, Wang D*. A coagulase-negative and non-haemolytic strain of Staphylococcus aureus for investigating the roles of SrtA in a murine model of bloodstream infection. Pathog Dis. 2015 Aug;73(6):ftv042.