个人简介

主要研究方向

食源性人兽共患寄生虫病

主要学术成果

科研项目：   
1.国家自然科学基金旋毛虫丝氨酸蛋白酶介导宿主高度免疫抑制的确证及其分子作用机制（项目编号：31872467）2019.01-2022.12
2.国家重点研发计划-课题旋毛虫病早期诊断与阻断及免疫预防制剂研发（项目编号：2017YFD0501302）2017.06-2020.12
3.国家重点研发计划-子课题食源性致病微生物新型危害因子和特异性监测新靶标挖掘（项目编号：2017YFC1601202）2018.01-2021.12
4.国家自然科学基金 旋毛虫种群遗传结构及功能基因定位研究（项目编号：31402185）2015.01-2017.12
5.教育部博士点新教师基金 旋毛虫丝氨酸蛋白酶在入侵宿主过程中的功能探究（项目编号：20130061120113）2014.01-2016.12
学术论文：   
1)    Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques. Xiaolei Liu, Yi Liu, Xuemin Jin, Zhanlong He Zhen Huang, Shumin Sun , Yu weiGao, Jingyu Li, Qin Ning, Zhongping Xie, Ningyi Jin, Mingyuan Liu. Signal Transduct Target Ther. 2022 Jul 7;7(1):219.
2)    β-Glucan-triggered Akkermansia muciniphila expansion facilitates the expulsion of intestinal helminth via TLR2 in mice. Jin X, Liu Y, Wang J, Wang X, Tang B, Liu M*, Liu X*. Carbohydr Polym. 2022 Jan 1;275:118719.   
3)    Dual-functional AuNP-triggered hybridization chain reaction for enhanced competitive immunosensing for Trichinella spiralis antibody in zoonosis screening. Ning Xua, Yan Liua, Yansong Li, Bin Tang, Chen Li, Mingyuan Liu, Yu Zhou*, Xiaolei Liu*. Sensors &Actuators:B.Chemical. 15 March 2023, Volume 379 , 133300
4)    Nrf2 Participates in M2 Polarization by Trichinella spiralis to Alleviate TNBS-Induced Colitis in Mice. Jin X, Bai X, Zhao Y, Dong Z, Pang J, Liu M*, Liu X*. Front Immunol. 2021 Jun 23;12:698494.
5)    Extracellular Vesicles Derived From Trichinella spiralis Muscle Larvae Ameliorate TNBS-Induced Colitis in Mice. Yang Y#, Liu X#, Zhang Y, Shi H, Jia W, Zhu H, Jia H, Liu M, Bai X. Front Immunol. 2020 Jun 11;11:1174.
6)    Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice. Xuemin Jin, Yi Liu, Isabelle Vallee, Gregory Karadjian, Mingyuan Liu, Xiaolei Liu. Front. Immunol., 28 July 2022.
7)    Rapid Quantum Dot Nanobead-mAb Probe-Based Immunochromatographic Assay for Antibody Monitoring of Trichinella spiralis Infection. Xu N, Liu Y, Li Y, Tang B, Liang X, Yang Y, Liu M, Liu X*, Zhou Y*. Int J Nanomedicine. 2021 Mar 29;16:2477-2486.
8)    Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella. Liu X, Feng Y, Bai X, Wang X, Qin R, Tang B, Yu X, Yang Y, Liu M, Gao F.    Commun Biol. 2021 Jan 29;4(1):134.   
9)    The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor-Mediated Alternative Activation of Macrophages. Xu N, Bai X, Liu Y, Yang Y, Tang B, Shi HN, Vallee I, Boireau P, Liu X*, Liu M*. J Immunol. 2021 Mar 1;206(5):963-977.   
10)    The immune protection induced by a serine protease from the Trichinella spiralis adult against Trichinella spiralis infection in pigs.  Xu D, Bai X, Xu J, Wang X, Dong Z, Shi W, Xu F, Li Y, Liu M*, Liu X*.    PLoS Negl Trop Dis. 2021 May 10;15(5):e0009408.
11)     Effects of Trichinella spiralis and its excretory/secretory products on autophagy of host muscle cells in vivo and in vitro. Hu X#, Liu X#, Bai X, Yang L, Ding J, Jin X, Li C, Zhang Y, Li Y, Yang Y*, Liu M*.    PLoS Negl Trop Dis. 2021 Feb 18;15(2): e0009040.
12)     Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner.  Jin X#, Liu X#, Ding J, Zhang L, Yang Y, Wang X, Yang Y*, Liu M*. PLoS Negl Trop Dis. 2020 Sep 25;14(9): e0008632.