个人简介

主要研究方向

1.微小隐孢子虫与宿主细胞的相互作用
2.贾第虫、新孢子虫的分子流行病学调查及免疫学诊断

主要学术成果

科研项目：   
1. 科技部政府间国际科技创新合作项目 寄生虫（隐孢子虫与贾第虫）的检测、分离与评估— PARADISE（项目编号：2022YFE0114500）  2022.09-2025.08
2. “十四五” 国家重点研发计划  寄生虫对宿主的识别、入侵和感染机制（项目编号：2022YFD1800200） 2022.11-2025.12
3. 吉林省科技发展计划重点研发项目  肉牛微小隐孢子虫荧光定量PCR检测试剂盒的研制（项目编号：20220202059N C） 2022.07-2025.06
4. 吉林省科技发展计划肉牛专项  吉林省肉牛重要疫病关键防控技术研究（项目编号：YD ZJ202203C G ZH 051） 2022.01-2024.12

代表性论文：   
1.    Liu M, Zhang D, Wang D, Wu X, Zhang Y, Yin J*, Zhu G*. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein. J Infect Dis. 2023 Jul 7:jiad243.
2.    Gao X#, Yin J#, Wang D, Li X, Zhang Y, Wang C, Zhang Y, Zhu G. Discovery of New Microneme Proteins in Cryptosporidium parvum and Implication of the Roles of a Rhomboid Membrane Protein (CpROM1) in Host-Parasite Interaction. Front Vet Sci. 2021;8:778560
3.    Li X#, Yin J#, Wang D, Gao X, Zhang Y, Wu M, Zhu G. The mucin-like, secretory type-I transmembrane glycoprotein GP900 in the apicomplexan Cryptosporidium parvum is cleaved in the secretory pathway and likely plays a lubrication role. Parasit Vectors. 2022 May 17;15(1):170
4.    Zhang T, Gao X, Wang D, Zhao J, Zhang N, Li Q, Zhu G, Yin J*. A Single-Pass Type I Membrane Protein from the Apicomplexan Parasite Cryptosporidium parvum with Nanomolar Binding Affinity to Host Cell Surface. Microorganisms. 2021 May 8;9(5):1015.
5.    Liu G, Jia L, Shao Q, Lu H, Zhao J, Yin J*. MicroRNA profiling of Neospora caninum tachyzoites (NC-1) using a high-throughput approach. Parasitol Res. 2021 Jun;120(6):2165-2174.
6.    Nie J#, Yin J#, Wang D, Wang C, Zhu G. Implication of Potential Differential Roles of the Two Phosphoglucomutase Isoforms in the Protozoan Parasite Cryptosporidium parvum. Pathogens. 2021 Dec 24;11(1):21
7.    Liu G, Su Y, Zhou M, Zhao J, Zhang T, Ahmad W, Lu H, Jiang N, Chen Q, Xiang M, Yin J*. Prevalence and molecular characterization of Giardia duodenalis isolates from dairy cattle in northeast China. Exp Parasitol. 2015 Jul;154:20-4.
8.    Yin J, Qu G, Cao L, Li Q, Fetterer R, Feng X, Liu Q, Wang G, Qi D, Zhang X, Miramontes E, Jenkins M, Zhang N, Tuo W. Characterization of Neospora caninum microneme protein 10 (NcMIC10) and its potential use as a diagnostic marker for neosporosis. Vet Parasitol. 2012 Jun 8;187(1-2):28-35
授权专利：   
1. 发明人：尹继刚，王东强，张天宇，邵青延，焦新。专利名称：一种微小隐孢子虫检测用TSP7多肽序列及其应用。专利号：201810519141.22. 授权日：20191104
2. 发明人：尹继刚，张天宇，王东强，邵青延，焦新。专利名称：一种微小隐孢子虫检测用TSP4多肽序列及用途。专利号：201810513813.9. 授权日：20191124
3. 发明人：向梅; 尹继刚; 王海礁; 陆慧君; 姜宁;陈启军。专利名称：一种弓形虫循环抗原双抗夹心ELISA检测方法。专利号：ZL201010264255.0. 授权日：20130911
4. 发明人：尹继刚，高依然，向梅，姜宁，陆慧君，陈启军。专利名称：一种诊断用微小隐孢子虫重组抗原。专利号：ZL201410011922.2. 授权日：20160420