个人简介

主要研究方向

食源性人兽共患寄生虫病

主要学术成果

1）科技部国家重点研发计划，项目，2017YFD0501300，畜禽重要人兽共患寄生虫病源头防控与阻断技术研究，2017-07至2020-12，1928（国拨1768）万元，主持（项目首席科学家）。
2）国家自然科学基金委员会，重点国际(地区)合作研究项目，NSFC31520103916，旋毛虫免疫抑制关键蛋白分子的分离、鉴定及其作用机制探究，2016.01-2020.12，249万元，结题，主持。
3）国家自然科学基金委员会，重点项目，NSFC31030064，我国重要食源性人兽共患旋毛虫病的病原侵袭与逃避机制研究，2011.01-2014.12，212万元，结题，主持。
4）中央军委科技委，项目，19-163-00-KX-003-002-01，应急治疗用马抗2019-nCoV血清的快速制备， 2020.03-2020.12，80万元，结题，主持。
4）广东省海外创新团队项目，横向企业开发项目（深圳市易瑞生物技术有限公司）：食源性寄生虫病的诊断抗原抗体研制，2014ZT05S123，2016-2019，200万元，项目负责人。
5）国家自然科学基金重点项目，我国重要食源性人兽共患旋毛虫病的病原侵袭与逃避机制研究，NSFC31030064，2011-2014，212万元，项目负责人。
6）国家杰出青年基金，旋毛虫与宿主间互作机制研究，NSFC30825033，2009-2012，200万元，主持。
7）科技部863重点项目课题，农村高发及危害严重的人兽共患病病种预防性疫苗的开发与研制，2011AA10A215，2011-2013，100万元，主持。
8）科技部传染病重大专项项目课题，旋毛虫与华支睾吸虫免疫标识性抗原的筛选及其应用研究，2008ZX10004-11，2008-2010，117万元，主持。
9）科技部863目标导向项目，高质量基因重组蛋白在人兽共患旋毛虫病诊断与检验中的应用，2006AA02Z451，2006-2009，180万元，主持。
1)    Liu X, Liu Y, Jin X, He Z, Huang Z, Sun S, Gao Y, Li J, Ning Q, Xie Z, Jin N, Liu M. Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques. Signal Transduct Target Ther. 2022 Jul 7;7(1):219. doi: 10.1038/s41392-022-01095-8. PMID: 35798694.
2)    Wang A, Liu X, Heckmann A, Caignard G, Vitour D, Hirchaud E, Liu M, Boireau P, Karadjian G, Vallée I. A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host's cell vimentin. Parasitol Res. 2022 Mar 23.
3)    Jin X, Liu Y, Wang J, Wang X, Tang B, Liu M, Liu X. β-Glucan-triggered Akkermansia muciniphila expansion facilitates the expulsion of intestinal helminth via TLR2 in mice. Carbohydr Polym. 2022 Jan 1;275:118719. doi: 10.1016/j.carbpol.2021.118719. 10.723
4)    Shi W, Xu N, Wang X, Vallée I, Liu M, Liu X. Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives. J Inflamm Res. 2022 Jan 21;15:475-491. doi: 10.2147/JIR.S348079.
5)    Ding J, Tang B, Liu X, Bai X, Wang Y, Li S, Li J, Liu M, Wang X. Excretory- secretory product of Trichinella spiralis inhibits tumor cell growth by regulating the immune response and inducing apoptosis. Acta Trop. 2022 Jan;225:106172. doi: 10.1016/j.actatropica.2021.106172.
6)    Liu Y, Dong Z, Pang J, Liu M, Jin X. Prevalence of meat-transmitted Taenia and Trichinella parasites in the Far East countries. Parasitol Res. 2021 Dec;120(12):4145-4151. doi: 10.1007/s00436-021-07124-9.
7)    Hu X, Liu X, Li C, Zhang Y, Li C, Li Y, Chen Y, Guo H, Bai X, Liu M. Time-resolved transcriptional profiling of Trichinella-infected murine myocytes helps to elucidate host-pathogen interactions in the muscle stage. Parasit Vectors. 2021 Mar 1;14(1):130. doi: 10.1186/s13071-021-04624-6.
8)    Wang N, Bai X, Jin X, Tang B, Yang Y, Sun Q, Li S, Wang C, Chang Q, Liu M, Liu X. The dynamics of select cellular responses and cytokine expression profiles in mice infected with juvenile Clonorchis sinensis. Acta Trop. 2021 May;217:105852. doi: 10.1016/j.actatropica.2021.105852.
9)    Gao X, Yang Y, Liu X, Wang Y, Yang Y, Boireau P, Liu M, Bai X. Extracellular vesicles derived from Trichinella spiralis prevent colitis by inhibiting M1 macrophage polarization. Acta Trop. 2021 Jan;213:105761. doi: 10.1016/j.actatropica.2020.105761.
10)    Xu D, Bai X, Xu J, Wang X, Dong Z, Shi W, Xu F, Li Y, Liu M, Liu X. The immune protection induced by a serine protease from the Trichinella spiralis adult against Trichinella spiralis infection in pigs. PLoS Negl Trop Dis. 2021 May 10;15(5):e0009408. doi: 10.1371/journal.pntd.0009408.
11)    Wang Y, Bai X, Tang B, Zhang Y, Zhang L, Cai X, Lin J, Jia W, Boireau P, Liu M, Liu X. Comparative analysis of excretory-secretory products of muscle larvae of three isolates of Trichinella pseudospiralis by the iTRAQ method. Vet Parasitol. 2021 Sep;297:109119. doi: 10.1016/j.vetpar.2020.109119.
12)    Liu X, Feng Y, Bai X, Wang X, Qin R, Tang B, Yu X, Yang Y, Liu M, Gao F. Comparative multi-omics analyses reveal differential expression of key genes relevant for parasitism between non-encapsulated and encapsulated Trichinella. Commun Biol. 2021 Jan 29;4(1):134. doi: 10.1038/s42003-021-01650-z.    6.548
13)    Jin X, Bai X, Zhao Y, Dong Z, Pang J, Liu M, Liu X. Nrf2 Participates in M2 Polarization by Trichinella spiralis to Alleviate TNBS-Induced Colitis in Mice. Front Immunol. 2021 Jun 23;12:698494. doi: 10.3389/fimmu.2021.698494. 8.786
14)    Feng Y, Liu X, Liu Y, Tang B, Bai X, Li C, Wang X, Deng Y, Gao F, Liu M. Comparative Epigenomics Reveals Host Diversity of the Trichinella Epigenomes and Their Effects on Differential Parasitism. Front Cell Dev Biol. 2021 Jun 11;9:681839. doi: 10.3389/fcell.2021.681839.
15)    Wang X, Tang B, Zhao Y, Ding J, Wang N, Liu Y, Dong Z, Sun X, Xu Q, Liu M, Liu X. Development of a rapid and sensitive immunochromatographic strip based on EuNPs-ES fluorescent probe for the detection of early Trichinella spiralis-specific IgG antibody in pigs. Vet Res. 2021 Jun 11;52(1):85. doi:10.1186/s13567-021-00951-9.
16)    Hu X, Liu X, Bai X, Yang L, Ding J, Jin X, Li C, Zhang Y, Li Y, Yang Y, Liu M. Effects of Trichinella spiralis and its excretory/secretory products on autophagy of host muscle cells in vivo and in vitro. PLoS Negl Trop Dis. 2021 Feb 18;15(2):e0009040. doi: 10.1371/journal.pntd.0009040.
17)    Liu Y, Liu X, Li Y, Xu N, Yang Y, Liu M, Zhou Y. Evaluation of a cystatin-like protein of Trichinella spiralis for serodiagnosis and identification of immunodominant epitopes using monoclonal antibodies. Vet Parasitol. 2021 Sep;297:109127. doi: 10.1016/j.vetpar.2020.109127.
18)    Jin X, Yang Y, Ding J, Liu X, Shi H, Luo X, Jia W, Cai X, Vallee I, Boireau P, Bai X, Liu M. Nod-like receptor pyrin domain containing 3 plays a key role in the development of Th2 cell-mediated host defenses against Trichinella spiralis infection. Vet Parasitol. 2021 Sep;297:109159. doi: 10.1016/j.vetpar.2020.109159.
19)    Li C, Bai X, Liu X, Zhang Y, Liu L, Zhang L, Xu F, Yang Y, Liu M. Disruption of Epithelial Barrier of Caco-2 Cell Monolayers by Excretory Secretory Products of Trichinella spiralis Might Be Related to Serine Protease. Front Microbiol. 2021 Mar 17;12:634185. doi: 10.3389/fmicb.2021.634185.
20)    Wang N, Bai X, Ding J, Lin J, Zhu H, Luo X, Fu Z, Zhu C, Jia H, Liu M, Liu X. Trichinella infectivity and antibody response in experimentally infected pigs. Vet Parasitol. 2021 Sep;297:109111. doi: 10.1016/j.vetpar.2020.109111.
21)    Zhang D, Qi Y, Cui Y, Song W, Wang X, Liu M, Cai X, Luo X, Liu X, Sun S. Rapid Detection of Cysticercus cellulosae by an Up-Converting Phosphor Technology-Based Lateral-Flow Assay. Front Cell Infect Microbiol. 2021 Nov 10;11:762472. doi: 10.3389/fcimb.2021.762472. PMID: 34858877; PMCID: PMC8631268.
22)    Liu Y, Xu N, Li Y, Tang B, Yang H, Gao W, Liu M, Liu X, Zhou Y. Recombinant cystatin-like protein-based competition ELISA for Trichinella spiralis antibody test in multihost sera. PLoS Negl Trop Dis. 2021 Aug 25;15(8):e0009723. doi: 10.1371/journal.pntd.0009723. PMID: 34432796; PMCID: PMC8423253.
23)    Li Y, Zhang H, Liu M, Guo W, Yu L. Microglia NLRP3 Inflammasomes Activation Involving Diabetic Neuroinflammation in Diabetic Mice and BV2 Cells. Curr Pharm Des. 2021;27(24):2802-2816. doi: 10.2174/1381612827666210716104606. PMID: 34279193.
24)    Xu N, Liu Y, Li Y, Tang B, Liang X, Yang Y, Liu M, Liu X, Zhou Y. Rapid Quantum Dot Nanobead-mAb Probe-Based Immunochromatographic Assay for Antibody Monitoring of Trichinella spiralis Infection. Int J Nanomedicine. 2021 Mar 29;16:2477-2486. doi: 10.2147/IJN.S304845. PMID: 33824586; PMCID: PMC8018372.
25)    Li J, Ding J, Liu XL, Tang B, Bai X, Wang Y, Qiao WD, Liu MY, Wang XL. Upconverting phosphor technology-based lateral flow assay for the rapid and sensitive detection of anti-Trichinella spiralis IgG antibodies in pig serum. Parasit Vectors. 2021 Sep 22;14(1):487. doi: 10.1186/s13071-021-04949-2. PMID: 34551787; PMCID: PMC8456594.
26)    Wang X, Song W, Ji G, Song Y, Liu X, Luo X, Liu M, Sun S. Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses. Hereditas. 2021 Aug 12;158(1):28. doi: 10.1186/s41065-021-00195-9. PMID: 34384501; PMCID: PMC8361615.
27)    Li Y, Long W, Gao M, Jiao F, Chen Z, Liu M, Yu L. TREM2 Regulates High Glucose-Induced Microglial Inflammation via the NLRP3 Signaling Pathway. Brain Sci. 2021 Jul 7;11(7):896. doi: 10.3390/brainsci11070896. PMID: 34356130; PMCID: PMC8306970.
28)    Xu N, Bai X, Liu Y, Yang Y, Tang B, Shi HN, Vallee I, Boireau P, Liu X, Liu M. The Anti-Inflammatory Immune Response in Early Trichinella spiralis Intestinal Infection Depends on Serine Protease Inhibitor-Mediated Alternative Activation of Macrophages. J Immunol. 2021 Mar 1;206(5):963-977. doi: 10.4049/jimmunol.2000290. Epub 2021 Jan 25. PMID: 33495238; PMCID: PMC7887736.
29)    Wang N, Bai X, Ding J, Lin J, Zhu H, Luo X, Fu Z, Zhu C, Jia H, Liu M, Liu X. Trichinella infectivity and antibody response in experimentally infected pigs. Vet Parasitol. 2020 Apr 18:109111. doi: 10.1016/j.vetpar.2020.109111.
30)    Jin X, Bai X, Yang Y, Ding J, Shi H, Fu B, Boireau P, Liu M, Liu X. NLRP3 played a role in Trichinella spiralis-triggered Th2 and regulatory T cells response. Vet Res. 2020 Aug 27;51(1):107. doi: 10.1186/s13567-020-00829-2.
31)    Li TT, Tang B, Bai X, Wang XL, Luo XN, Yan HB, Zhu HF, Jia H, Liu XL, Liu MY. Development of genome-wide polymorphic microsatellite markers for Trichinella spiralis. Parasit Vectors. 2020 Feb 11;13(1):58. doi: 10.1186/s13071-020-3929-2.
32)    Yang Y, Liu L, Liu X, Zhang Y, Shi H, Jia W, Zhu H, Jia H, Liu M, Bai X. Extracellular Vesicles Derived From Trichinella spiralis Muscle Larvae Ameliorate TNBS-Induced Colitis in Mice. Front Immunol. 2020 Jun 11;11:1174. doi: 10.3389/fimmu.2020.01174.
33)    Xu D, Tang B, Yang Y, Cai X, Jia W, Luo X, Yan H, Zhang Z, Lin J, Liu M, Liu X. Vaccination with a DNase II recombinant protein against Trichinella spiralis infection in pigs. Vet Parasitol. 2020 Mar 5:109069. doi: 10.1016/j.vetpar.2020.109069.
34)    Wang N, Bai X, Tang B, Yang Y, Wang X, Zhu H, Luo X, Yan H, Jia H, Liu M, Liu X. Primary characterization of the immune response in pigs infected with Trichinella spiralis. Vet Res. 2020 Feb 21;51(1):17. doi: 10.1186/s13567-020-0741-0.
35)    Jin X, Liu X, Ding J, Zhang L, Yang Y, Wang X, Yang Y, Liu M. Lentinan improved the efficacy of vaccine against Trichinella spiralis in an NLRP3 dependent manner. PLoS Negl Trop Dis. 2020 Sep 25;14(9):e0008632. doi: 10.1371/journal.pntd.0008632.
36)    Wang Y, Bai X, Tang B, Zhang Y, Zhang L, Cai X, Lin J, Jia W, Boireau P, Liu M, Liu X. Comparative analysis of excretory-secretory products of muscle larvae of three isolates of Trichinella pseudospiralis by the iTRAQ method. Vet Parasitol. 2020 Apr 22:109119. doi: 10.1016/j.vetpar.2020.109119.
37)    Jin X, Yang Y, Ding J, Liu X, Shi H, Luo X, Jia W, Cai X, Vallee I, Boireau P, Bai X, Liu M. Nod-like receptor pyrin domain containing 3 plays a key role in the development of Th2 cell-mediated host defenses against Trichinella spiralis infection. Vet Parasitol. 2020 Jun 1:109159. doi: 10.1016/j.vetpar.2020.109159.
38)    Pang J, Ding J, Zhang L, Zhang Y, Yang Y, Bai X, Liu X, Jin X, Guo H, Yang Y, Liu M. Effect of recombinant serine protease from adult stage of Trichinella spiralis on TNBS-induced experimental colitis in mice. Int Immunopharmacol. 2020 Sep;86:106699. doi: 10.1016/j.intimp.2020.106699.