基本信息

姓 名：杨瑞馥

出生年月：1963.07

性 别：男

行政职务：实验室主任

工作单位：军事医学科学院军事兽医研究所

职 称：研究员

学科专业：预防兽医学

研究方向：微生物学

讲授课程：

招生专业：

是否博导：是

现指导博士生数：

个人情况综述

杨瑞馥为军事医学科学院微生物流行病研究所的研究员，在致病细菌学，尤其是鼠疫耶尔森氏菌的研究中突出的成绩，他领导的团队发表的论文，受到国内外同行的关注，被引用近300余次，他们的研究成果大多发表在微生物学领域的著名杂志，如《Journal of Bacteriology》、《Infection and Immunity》、《Microbe and Infection》、《Emerging Infectious Disease》和《Applied Environmental Microbiology》等；同时，在一些综合性杂志也发表了一系列论文，如《Analytical Chemistry》、《PLOS One》、《BMC Genomics》、《Journal of Molecular Biology》、《Proteomics》和《Clinical Chemistry》等；他们发表的论文曾经被《Nature Reviews Microbiology》杂志专门评述，多篇论文在所发表杂志的网站下载前20名排行中名列前茅，在他们的研究工作基础上，还在本专业著名杂志上（《Infection and Immunity》和《Microbe and Infection》等）发表了一系列综述性评论。

学习工作简历

2002年在军事医学科学院获得微生物学专业博士学位。

社会学术兼职

中国微生物学会常务理事；中国微生物学会分析微生物学专业委员会主任委员；国家卫生部自然疫源性疾病专家咨询委员会委员；国家处置生物恐怖袭击事件专家咨询组成员；《微生物学学报》编委；《中华预防医学杂志》编委；《解放军预防医学杂志》编委成员；《解放军医学杂志》编委成员；《军事医学科学院院刊》编委成员。

教学工作

主要科研方向

致病细菌学，尤其是鼠疫耶尔森氏菌的研究。

主要科研项目

主要科研成果

近5年来，发表Sci论文70余篇，影响因子200以上，被引用300余次；主编专著5部；获得省部级科技进步二等奖2项；获得发明专利5项，实用新型5项；代表性论文如下： 1.Zhou D, Yang R. Molecular Darwinian evolution of virulence in Yersinia pestis. Infect Immun. 2009 Mar 16. [Epub ahead of print]

2.Bi Y, Du Z, Han Y, Guo Z, Tan Y, Zhu Z, Yang R. Yersinia pestis and host macrophages: immunodeficiency of mouse macrophages induced by YscW. Immunology. 2008 Dec 18. [Epub ahead of print]

3.Yang R, Guo X, Yang J, Jiang Y, Pang B, Chen C, Yao Y, Qin J, Li Q. Genomic research for important pathogenic bacteria in China. Sci China C Life Sci. 2009 Jan;52(1):50-63.

4.Du Z, Tan Y, Yang H, Qiu J, Qin L, Wang T, Liu H, Bi Y, Song Y, Guo Z, Han Y, Zhou D, Wang X, Yang R. Gene expression profiling of Yersinia pestis with deletion of lcrG, a known negative regulator for Yop secretion of type III secretion system. Int J Med Microbiol. 2008 Dec 22. [Epub ahead of print]

5.Han H, Wong HC, Kan B, Guo Z, Zeng X, Yin S, Liu X, Yang R, Zhou D. Genome plasticity of Vibrio parahaemolyticus: microevolution of the 'pandemic group'. BMC Genomics. 2008 Nov 28;9:570.

6.Bi Y, Liu G, Yang R. MicroRNAs: novel regulators during the immune response. J Cell Physiol. 2009 Mar;218(3):467-72.

7.Qiu J, Guo Z, Liu H, Zhou D, Han Y, Yang R. DNA microarray-based global transcriptional profiling of Yersinia pestis in multicellularity. J Microbiol. 2008 Oct;46(5):557-63.

8.Liu H, Wang H, Qiu J, Wang X, Guo Z, Qiu Y, Zhou D, Han Y, Du Z, Li C, Song Y, Yang R. Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host. J Basic Microbiol. 2009 Feb;49(1):92-9.

9.Cui Y, Li Y, Gorgé O, Platonov ME, Yan Y, Guo Z, Pourcel C, Dentovskaya SV, Balakhonov SV, Wang X, Song Y, Anisimov AP, Vergnaud G, Yang R. Insight into microevolution of Yersinia pestis by clustered regularly interspaced short palindromic repeats. PLoS ONE. 2008 Jul 9;3(7):e2652.

10.Wang T, Qi Z, Wu B, Zhu Z, Yang Y, Cui B, Dai R, Zhang Q, Qiu Y, Wang Z, Wang H, Guo Z, Wang X, Yang R. A new purification strategy for fraction 1 capsular antigen and its efficacy against Yersinia pestis virulent strain challenge. Protein Expr Purif. 2008 Sep;61(1):7-12.

11. Li Y, Dai E, Cui Y, Li M, Zhang Y, Wu M, Zhou D, Guo Z, Dai X, Cui B, Qi Z, Wang Z, Wang H, Dong X, Song Z, Zhai J, Song Y, Yang R. Different region analysis for genotyping Yersinia pestis isolates from China. PLoS ONE. 2008 May 14;3(5):e2166.

12. Han Y, Geng J, Qiu Y, Guo Z, Zhou D, Bi Y, Du Z, Song Y, Wang X, Tan Y, Zhu Z, Zhai J, Yang R. Physiological and regulatory characterization of KatA and KatY in Yersinia pestis. DNA Cell Biol. 2008 Aug;27(8):453-62.

13.Li Y, Gao H, Qin L, Li B, Han Y, Guo Z, Song Y, Zhai J, Du Z, Wang X, Zhou D, Yang R. Identification and characterization of PhoP regulon members in Yersinia pestis biovar Microtus. BMC Genomics. 2008 Mar 27;9:143.

14.Li B, Yang R. Interaction between Yersinia pestis and the host immune system. Infect Immun. 2008 May;76(5):1804-11.

15.Li B, Zhou D, Wang Z, Song Z, Wang H, Li M, Dong X, Wu M, Guo Z, Yang R. Antibody profiling in plague patients by protein microarray. Microbes Infect. 2008 Jan;10(1):45-51.

16.Yanping Han, Jingfu Qiu, Zhaobiao Guo, He Gao, Yajun Song, Dongsheng Zhou andRuifu Yang(co-corresponding author)：Comparative transcriptomics in Yersinia pestis: a global view of environmental modulation of gene expression. BMC Microbiol. 2007 Oct 29;7(1):96 [Epub ahead of print] doi:10.1186/1471-2180-7-96

17.Hong-Bo Jing1, Jing Yuan, JieWang, Yuan Yuan, Li Zhu1, Xian-Kai Liu,Yu-Ling Zheng1, Kai-HuaWei, Xue-Min Zhang, Hong-Ran Geng, Qing Duan,Shu-Zhang Feng,Rui-Fu Yang(co-corresponding author), Wu-Chun Cao, Heng-LiangWang and Yong-Qiang Jiang: Proteome analysis of Streptococcus suis serotype 2. Proteomics 2007 DOI 10.1002/pmic.200600930

18.Chen Chen, Jiaqi Tang, Wei Dong, Changjun Wang, Youjun Feng, Jing Wang, Feng Zheng, Xiuzhen Pan, Di Liu, Ming Li, Yajun Song, Xinxing Zhu, Haibo Sun, Tao Feng, Zhaobiao Guo, Aiping Ju, Junchao Ge, Yaqing Dong, Wen Sun, Yongqiang Jiang, Jun Wang, Jinghua Yan, Huanming Yang, Xiaoning Wang, George F. Gao,Ruifu Yang(co-corresponding author), Jian Wang, Jun Yu: A Glimpse of Streptococcal Toxic Shock Syndrome from Comparative Genomics of S. suis 2 Chinese Isolates. PLoS ONE 2007 2(3): e315. doi:10.1371/journal.pone.0000315

19.Hua Wei, Zhaobiao Guo, Ziwen Zhu, Yafang Tan, Zongmin Du,Ruifu Yang(co-corresponding author). Sensitive detection of antibody against antigen F1 ofYersinia pestisby an antigen sandwich method using a portable fiber optic biosensor. Sensors and Actuators B. 127 (2007) 525–530

20.Hua Wei, Yongkai Zhao, Yujing Bi, Haihong Liu, Zhaobiao Guo, Yajun Song, Junhui Zhai, Huijie Huang,Ruifu Yang(corresponding author). Direct detection of Yersinia pestis from the infected animal specimens by a fiber optic biosensor. Sensors and Actuators B 123 (2007) 204–210

21.Haihong Liu, Zongmin Du, Jin Wang, andRuifu Yang (corresponding author). Universal Sample Preparation Method for Characterization of Bacteria by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry. Appl Environm Microbiol. 2007 73(6): 1899-1907.

22.Zhongqiang Yan, Lei Zhou, Yongkai Zhao,Jing Wang, Lihua Huang, Kongxin Hu, Haihong Liu,Hong Wang, Zhaobiao Guo, Yajun Song, Huijie Huang,Ruifu Yang(corresponding author). Rapid quantitative detection of Yersinia pestis by lateral-flow immunoassay and up-converting phosphor technology-based biosensor. Sensors and Actuators B. 119 (2006):656-663

23.Dongsheng Zhou, Long Qin, Yanping Han, Jingfu Qiu, Zeliang Chen, Bei Li, Yajun Song, Jin Wang,Zhaobiao Guo, Junhui Zhai, Zongmin Du, Xiaoyi Wang &Ruifu Yang(corresponding author). Global analysis of iron assimilation and Fur regulation in Yersinia pestis. FEMS Microbiol Lett 258 (2006) 9–17

24.Xiaoyi Wang, Dongsheng Zhou, Long Qin, Erhei Dai, Jianguo Zhang, Yanping Han, Zhaobiao Guo, Yajun Song, Jun Wang,Ruifu Yang(corresponding author). Genomic comparison of Yersinia pestis and Yersinia pseudotuberculosis by combination of suppression subtractive hybridization and DNA microarray Arch Microbiol (2006) 186:151–159

25.Yajun Song, Erhei Dai, Jin Wang, Hengjun Liu, Junhui Zhai, Cuiying Chen, Zongmin Du,Zhaobiao Guo,Ruifu Yang(corresponding author). Genotyping of hepatitis B virus (HBV) by oligonucleotides microarray Molecular and Cellular Probes 20:121-127

26. Jingfu Qiu, Dongsheng Zhou, Long Qin, Yanping Han, Xiaoyi Wang, Zongmin DU, Yajun Song &Ruifu Yang(corresponding author). Microarray expression profiling ofYersinia pestisin response to chloramphenicol. FEMS Microbiol Lett 263 (2006) 26–31

27.Dongsheng Zhou, Yanping Han, Jingfu Qiu, Long Qin, Zhaobiao Guo,Xiaoyi Wang, Yajun Song, Yafang Tan, Zongmin Du,Ruifu Yang(corresponding author). Genome-wide transcriptional response of Yersinia pestis to stressful conditions simulating phagolysosomal environments.Microbes and Infection 8 (2006) 2669-2678

28.Zeliang Chen, Bei Li, Jianshan Zhang, Long Qin, Dongsheng Zhou, Yanping Han, Zongmin Du, Zhaobiao Guo, Yajun Song,Ruifu Yang(corresponding author). Quorum sensing affects virulence-associated proteins F1,LcrV, KatY and pH6 etc. of Yersinia pestis as revealed by protein microarray-based antibody profiling Microbes and Infection 8(2006) 2501-2508

代表性专著：

1.杨瑞馥、汪建、翟俊辉主编《急性呼吸窘迫综合征》军事医学科学出版社， 2004年1月出版。

2.杨瑞馥、宋亚军主编《微生物法医学》化工出版社 2004年12月出版

3.陶天申 杨瑞馥 东秀珠主编《原核生物系统学》化工出版社 2007年9月出版杨瑞馥 主编《防生物危害医学》，军事医学科学出版社，2008年2月出版。

获奖信息

杨瑞馥研究员于2005年获得国家自然科学基金杰出青年基金，并承担了国家自然科学基金重点项目、863和973项目。